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To better understand why studies of topical and oral supplemental administration of antibiotics have not conclusively shown efficacy in preventing post-operative endophthalmitis, and when they may be effective
Mathematical models of intracameral antibiotic concentration decay in the anterior chamber compared to resistance levels were created to better understand the duration of antibacterial efficacy of intracameral administration of prophylactic antibiotics. The additional anterior chamber concentration effects of topical and oral supplementation were determined and plotted.
Graphs of antibiotic concentration decay were drawn illustrating what happens under various assumptions. The results are consistent with experimental data from the literature.
The study of models of intracameral antibiotic concentration decay can enhance our understanding of the effects of our current protocols and suggest better practices.